TIGP (BP) - Using single-cell RNA-seq technology to reveal the role of tissue resident memory (TRM) T-cells in Breast Cancer
- 講者Agus Salim 博士 (拉籌伯大學數學與統計系)
邀請人：TIGP BP Program - 時間2018-09-27 (Thu.) 14:00 ~ 16:00
- 地點Auditorium 101 at IIS New Building
摘要
Using Chromium 10X technology, we performed single-cell RNA sequencing (scRNA-seq) of 6,311 T cells isolated from human BCs. We demonstrate that BCs with a high number of Tumor Inflitrating Lymphocytes (TILs) contained CD8+ T cells with features of tissue-resident memory T (TRM) cell differentiation and that these CD8+ TRM cells expressed high levels of immune checkpoint molecules and effector proteins. A CD8+ TRM gene signature developed from the scRNA-seq data was significantly associated with improved patient survival in early-stage triple-negative breast cancer (TNBC) and provided better prognostication than CD8 expression alone.