TIGP (BIO)– Imaging Mitochondria Dynamics
- LecturerDr. Hsueh-Fen Juan (Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University)
Host: TIGP- Bioinformatics Program - Time2019-11-21 (Thu.) 14:00 ~ 16:00
- LocationAuditorium 101 at IIS new Building
Abstract
Mitochondria are crucial organelles that provide energy through oxidative phosphorylation in eukaryotic cells and also play critical roles in biological processes including growth, division, cell cycle, apoptosis and calcium homeostasis, as well as rapid adaptation to meet the metabolic needs of the cells. Mitochondrial morphologies have dynamic changes with fission (fragmentation) and fusion (elongation) in different cell types and stress such as hypoxia and nutrient starvation. Mitochondria in cancer cells often exhibit fragmented and rounded structures, while fission enhancement or fusion reduction promotes cancer proliferation, invasion and metastasis. Modulating mitochondrial dynamics could be a potential therapeutic target. Hence imaging mitochondria dynamics become an important issue to understand biological processes and disease progression. In this talk, I will present imaging mitochondria dynamics for analysis of key protein trafficking in cancer cells and study of cyclic stretching.