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Cooperative mechanism in epigenetic network controls gene expression quantity.

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Cooperative mechanism in epigenetic network controls gene expression quantity.

  • 講者Mariko Okada 教授 (Institute for Protein Research, Osaka University)
    邀請人:蔡懷寬
  • 時間2019-11-20 (Wed.) 10:30 ~ 12:30
  • 地點資訊所新館106演講廳
摘要

 

Gene expression is controlled by signaling activities and epigenetic regulation. To understand quantitative mechanism of gene regulatory machinery, we analyze multi-omics data on histone modification, chromatin accessibility and single cell mRNA expression using a mathematical model. Our study using antigen-stimulated B cell indicated that multiple binding of NF-kB transcription factor on chromatin accessible region of the longer size of enhancer can induce higher level of gene expression than that is controlled by fewer binding of the NF-kB on the shorter size of enhancer. Our analysis indicates that the enhancer length is critical for quantitative control of gene expression. Imaging analysis further indicated that a cooperativity in transcription factor interaction arises from liquid-liquid phase separation in nucleus might be responsible for the event.

 

BIO

 

1988                Graduate School, Tokyo University of Agriculture and Technology (Major in Biochemistry), Japan

1988 – 1996    Research Scientist, Group Leader, Manager, Novo Nordisk Bioindustry, Ltd.

1996 – 1999    Visiting Researcher, Institute of Toxicology and Environmental Health, University of California, Davis, USA.

2000 – 2016     Research Scientist, Senior Research Scientist, Team leader, RIKEN Institute, Japan

2016 –  present Professor, Institute for Protein Research, Osaka University, Japan